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Tolerance to the anticonvulsant consequences of clonazepam takes place in both of those animals and human beings. In individuals, tolerance towards the anticonvulsant consequences of clonazepam occurs frequently.[seventy six][seventy seven] Continual usage of benzodiazepines can lead to the development of tolerance with a minimize of benzodiazepine binding web sites.

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A gradual reduction in dosage reduces the severity in the benzodiazepine withdrawal syndrome. Due to challenges of tolerance and withdrawal seizures, clonazepam is normally not proposed for that extensive-term administration of epilepsies. Increasing the dose can triumph over the consequences of tolerance, but tolerance to the higher dose might manifest and adverse effects could intensify. The mechanism of tolerance consists of receptor desensitization, down regulation, receptor decoupling, and alterations in subunit composition and in gene transcription coding.[eight]

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